Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome

Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome

Restless Legs Syndrome (RLS), first chronicled by Willis in 1672 and described in more detail by Ekbom in 1945, is a prevalent sensorimotor neurological disorder (5%-10% in the population) with a circadian predilection for the evening and night. Characteristic clinical features also include a compelling urge to move during periods of rest, relief with movement, involuntary movements in sleep (v...

Restless Legs Syndrome and Leg Motor Restlessness in Parkinson's Disease

Sleep disturbances are important nonmotor symptoms in Parkinson's disease (PD) that are associated with a negative impact on quality of life. Restless legs syndrome (RLS), which is characterized by an urge to move the legs accompanied by abnormal leg sensations, can coexist with PD, although the pathophysiology of these disorders appears to be different. RLS and PD both respond favorably to dop...

Is restless legs syndrome a sleep disorder?

A compelling urge to move the legs, often accompanied by uncomfortable dysesthesias, is the fundamental element of restless legs syndrome (RLS). To make a diagnosis of RLS, this core sensory-motor symptom must be present at rest, at least temporarily relieved by movement, and most pronounced at night. Sleep disturbance is usually present in RLS and is traditionally considered as a consequence o...

Restless Legs Syndrome Prevalence in Major Thalasemia Tabriz Children Hospital

The restless legs syndrome.

The first description of the restless legs syndrome (RLS) is attributed to Thomas Willis in the 'London Practice of Physick' of 1685 (Ekbom, 1960). Here he wrote 'wherefore to some, when being a bed they betake themselves to sleep, presently in the arms and leggs, leapings and contractions of their tendons, and so great a restlessness and tossings of their members ensue, that the diseased are n...